In the Texans' Week 8 Thursday Night Football matchup with the Miami Dolphins, Hopkins did the impossible.
With Dolphins cornerback Xavien Howard draped all over him, Hopkins skied and got his left paw on a high pass from Deshaun Watson.
Due to the way he jumped and how the ball came off his hand, Hopkins then had to direct the pigskin between his own legs so he could secure the catch.
It was part Odell Beckham Jr. and part Vince Carter.
Unfortunately, a bogus offensive pass interference call on Hopkins wiped out the play.
"That wasn't pass interference there," Hopkins told NFL Network after the game. "I think I amazed myself on that one. I definitely amazed myself on that one. I'm going to count that catch. That's a catch in my book."
It's a catch in our book, too, DeAndre—and one of the greatest in football history at that.
Hopkins did finish the game with two touchdowns and the Texans won big, so he got the last laugh.